{"id":15194,"date":"2025-10-27T15:19:07","date_gmt":"2025-10-27T14:19:07","guid":{"rendered":"https:\/\/carigest.ch\/portfolio-item\/universite-de-geneve-explorer-le-transportome-des-metabolites-essentiels-des-apicomplexa\/"},"modified":"2026-02-24T09:48:13","modified_gmt":"2026-02-24T08:48:13","slug":"universite-de-geneve-explorer-le-transportome-des-metabolites-essentiels-des-apicomplexa","status":"publish","type":"portfolio-item","link":"https:\/\/carigest.ch\/de\/portfolio-item\/universite-de-geneve-explorer-le-transportome-des-metabolites-essentiels-des-apicomplexa\/","title":{"rendered":"Universit\u00e9 de Gen\u00e8ve „Explorer le transportome des m\u00e9tabolites essentiels des Apicomplexa“"},"content":{"rendered":"\t\t
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\n\t\tExplorer le transportome des m\u00e9tabolites essentiels des Apicomplexa\t<\/h1>\n\t\t\t\t\t\t

Universit\u00e9 de Gen\u00e8ve, D\u00e9partement de microbiologie et m\u00e9decine mol\u00e9culaire<\/p><\/div>\n\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\tDescription\t<\/h2>\n\t\t\t

La Professeure Dominique Soldati-Favre<\/strong>, du D\u00e9partement de microbiologie et m\u00e9decine mol\u00e9culaire de l\u2019Universit\u00e9 de Gen\u00e8ve, m\u00e8ne depuis 2023 un projet de recherche visant \u00e0 \u00e9lucider les structures et les \u00e9changes mol\u00e9culaires impliqu\u00e9s lors de l\u2019infection par certains parasites, notamment Plasmodium (agent de la malaria) et Toxoplasme, deux pathog\u00e8nes d\u2019importance majeure en sant\u00e9 publique.<\/p>

Gr\u00e2ce \u00e0 une combinaison de m\u00e9thodes exp\u00e9rimentales avanc\u00e9es, son \u00e9quipe a pu caract\u00e9riser la structure et la fonction de plusieurs composants cl\u00e9s intervenant dans le processus d\u2019invasion des cellules h\u00f4tes et dans la r\u00e9plication intracellulaire de ces parasites. Ces travaux ont conduit \u00e0 l\u2019identification de nouvelles prot\u00e9ines essentielles \u00e0 leur survie et \u00e0 leur d\u00e9veloppement. <\/p>

Le soutien de la fondation donatrice conseill\u00e9e par CARIGEST SA a permis de concentrer ses recherches sur les m\u00e9canismes et les \u00e9changes mol\u00e9culaires n\u00e9cessaires \u00e0 l\u2019\u00e9tablissement de la phase chronique de l\u2019infection par Toxoplasme<\/strong>, laquelle se caract\u00e9rise par la formation de kystes persistants dans les tissus musculaires et c\u00e9r\u00e9braux.<\/p>

Ces recherches ouvrent la voie \u00e0 la d\u00e9finition de nouvelles cibles pour des approches th\u00e9rapeutiques innovantes et fournissent une base solide pour la mise en place de programmes de criblage mol\u00e9culaire<\/strong> \u00e0 haute affinit\u00e9, destin\u00e9s \u00e0 identifier des compos\u00e9s capables d\u2019inhiber la croissance et la persistance de ces parasites.<\/p>

L\u2019importance et la port\u00e9e de ces r\u00e9sultats sont attest\u00e9es par la publication de travaux dans des revues scientifiques internationales de tout premier plan.<\/p><\/div>\n\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\tSite Internet \t<\/h2>\n\t\t\t

Dominique SOLDATI-FAVRE - Microbiology and molecular medicine - UNIGE<\/a><\/span><\/p>

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L\u00e9gende photo: immunofluorescence montrant des kystes (en cyan) dans les cellules h\u00f4tes, contenant des bradyzo\u00eftes, responsables de l\u2019infection chronique par Toxoplasma gondii. Les parasites en magenta correspondent aux tachyzo\u00eftes, responsables de la phase aigu\u00eb de l\u2019infection. <\/em><\/p>

Cr\u00e9dit photo : \u00a9 Estefania Delgado Betancourt et Romuald Haase<\/em><\/p><\/div>\n\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Le projet de recherche du Professeure Dominique Soldati-Favre explore les m\u00e9canismes d\u2019infection et de survie intracellulaire des parasites Apicomplexa.<\/p>\n","protected":false},"author":11,"featured_media":15175,"menu_order":2,"template":"elementor_theme","portfolio-category":[43],"portfolio-tag":[],"class_list":["post-15194","portfolio-item","type-portfolio-item","status-publish","has-post-thumbnail","hentry","years-95","portfolio-category-zweck-1"],"yoast_head":"\nUniversit\u00e9 de Gen\u00e8ve "Explorer le transportome des m\u00e9tabolites essentiels des Apicomplexa" - Carigest SA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/carigest.ch\/de\/portfolio-item\/universite-de-geneve-explorer-le-transportome-des-metabolites-essentiels-des-apicomplexa\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Universit\u00e9 de Gen\u00e8ve "Explorer le transportome des m\u00e9tabolites essentiels des Apicomplexa" - 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